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Pseudomonas injection combined with chemotherapy on malignant pleural effusion clinical curative effect observation
Patients with pleural effusion in the base body, chemotherapy, respectively using Pseudomonas injection (PVI) and cisplatin (CDDP) intrapleural injection of grouping contrast observation, report as follows now; 1 case selection base group in 58 lung cancer with pleural effusion patients, treatment group 3O inverted, male 2L inverted, female 9, median at age 54 years (32 ~ 76), adenovirus type L5 inverted, small cell type 14, type 1 scales, which initially treated 22 inverted, retreatment was 8.
The control group was 28, male 15, female L3 inverted, the median age was 51 years (27 ~ 69), adenovirus type L6 inverted, small cell type 1O inverted, scale type 2. Initial treatment was 17, retreated l] pour.
2 methods of treatment of PVI by Qilu pharmaceutical factory produces per ampoule containing D, pumping, dead seedling body 12000000000.58 disease are chestnut with chemotherapy of CAV regimen (CTX60Omg / m, intravenous injection of VCRlmg / m, d1.
8.Intravenous injection of DL-8, ADM40mg / m *, intravenous injection, d), every 4 weeks for a cycle of chemotherapy, or El, to take a chest operation as far as possible pumping well net, the treatment group set for PVI M1 and NS20ml intrapleural injection of intramuscular injection of Dxm5mg (fever, severe pain when injected into the cavity at the same time 2 novocaine.
4m1); the control group using CDDP6Ong NS40ml method, back, chest water can help increase the weekly repeat a.After injection will catch prostrate and positioning the liquid uniform distribution.Observation methods and indexes of T chemotherapy before examination of blood analysis, urinalysis, liver function, chest X-ray film, B ultrasound, ECG, without obvious heart, liver, renal abnormalities and normal blood into group therapy} after chemotherapy weekly review blood analysis, the end of the treatment,sito moncler, comprehensive review, based on chest radiography judgment and evaluation of curative effect.
3 healing efficacy of standard (chestnut with Millar hesitating to set standards): CR (complete remission): only 1 wear flail liquid pumping well injection after thoracic surgery to reduce or is no longer increasing, symptom remission lasting 4 weeks.
PR (partial response): by the 2 liquid suction and injection to control your chest surgery does not increase and the remission of symptoms last week.NE (void) 2 Huan wear flail wok drainage and injection of medicine from the operation, still can not control and symptom exacerbation.
Results: the treatment group control group, see Table 1, 2 yuan.Comparison of curative effect of two groups were not statistically significant (P< 0.10 = 3.61).After PVI injection Xie role with fever, pain at the injection site.
Bereavement 1 treatment groups (30 PVI results of application) lost 2 pairs black group node bursts (28 inverted application CDDP 4 PVI) is a biological response modifier, is G a cell, the cell wall lipopolysaccharides (LPS) material.
The product of intrapleural injection, can increase the antigenic substance on pleural produce nonspecific flail bowel, caused by non-specific immune inflammatory reaction, make the shower l lymphocytes, fibroblasts, macrophages, epithelioid cells, Cheng Run, and pleural thickening, adhesion, permeability, leading to reduced or absorption of thoracic surgery.
According to He Zuze, PVI can live by macrophages. On cowpea (M), and phagocytosis and lysis of tumor cells and tumor cells are produced at the same time Mu transposition; tumor necrosis Tian Zi (TNF), interferon (IFN).
TNF can selectively make tumor necrosis and hemorrhage, and IFN in addition to directly inhibit further tumor cell proliferation, but also activation of NK, K, M cell.PVI AIX; C (antibody dependent cell mediated cytotoxicity cell Dan) activity increased, but also by promoting IL 2 induced LAKl precursor cells into LAK effector cells.